Developmental variations of plasma gamma-glutamyltransferase fractions in humans and in laboratory mammalians.
نویسندگان
چکیده
Plasma samples from human cord blood, and fetuses, newborns, and adults of different mammalians species were analyzed by gel-filtration chromatography, to ascertain whether gamma-glutamyltransferase (GGT) fractions reflect liver maturation. Human cord blood plasma showed higher b-, m-, and s-GGT fraction as compared to adult women. In rat and mouse fetuses and in newborns, b-GGT was the most abundant fraction. As in adult humans, in adult rats, mice, rabbits, sheep, and mini pigs, f-GGT was the most abundant fraction. GGT fractions are a common feature of all mammalian species tested. Their pattern changes seem to reflect liver postnatal maturation, function.
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ورودعنوان ژورنال:
- Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
دوره 17 1 شماره
صفحات -
تاریخ انتشار 2012